Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Tablet | Oral | |
| Tablet | Oral | 10 MG |
| Tablet | Oral | 20 MG |
| Tablet | Oral | 5 MG |
| Powder, for suspension | Oral | 0.006 g |
| Tablet | Oral | 5.,254 mg |
| Tablet, film coated | Oral | 10 mg/1 |
| Tablet, film coated | Oral | 20 mg/1 |
| Tablet | Oral | 12.5 mg |
| Tablet | Oral | 2.5 MG |
| Capsule, coated | Oral | 2.,5 mg |
| Capsule, coated | Oral | 5 mg |
| Tablet | Oral | 6 mg |
| Tablet | Oral | 30 MG |
| Tablet | Oral | 40 MG |
| Suspension | Oral | 1 mg/1mL |
| Suspension | Oral | 500 mcg/1mL |
| Syrup | 1 mg/1mL | |
| Tablet, film coated | Oral | 5 mg |
| Tablet | Oral | 5.,1 mg |
| Tablet, coated | Oral | 10 MG |
| Tablet | Oral | 10 mg/1 |
| Tablet | Oral | 2.5 mg/1 |
| Tablet | Oral | 20 mg/1 |
| Tablet | Oral | 5 mg/1 |
| Tablet, soluble | Oral | 10 mg/1 |
| Tablet, soluble | Oral | 2.,5 mg/1 |
| Tablet, soluble | Oral | 20 mg/1 |
| Tablet, soluble | Oral | 5 mg/1 |
| Tablet | Oral | |
| Tablet | Oral | 20., mg |
| Tablet | Oral | 2 mg |
| Tablet | Oral | 4 mg |
| Tablet | Oral | 8 mg |
| Tablet, film coated | Oral | 10 mg |
| Tablet, film coated | Oral | 20 mg |
Prices
| Unit description | Cost | Unit |
|---|---|---|
| Enalapril maleate powder | 9.,18USD | g |
| Enalaprilat 1.25 mg/ml vial | 3.6USD | ml |
| Vasotec 20 mg tablet | 3.36USD | tablet |
| Vaseretic 10-25 mg tablet | 3.15USD | tablet |
| Vasotec 10 mg tablet | 2.63USD | tablet |
| Vasotec 5 mg tablet | 2.08USD | tablet |
| Vasotec 2.5 mg tablet | 1.65USD | tablet |
| Enalapril maleate 20 mg tablet | 1.56USD | tablet |
| Vaseretic 5-12.,5 mg tablet | 1.49USD | tablet |
| Vasotec 20 mg Tablet | 1.34USD | tablet |
| Vasotec 10 mg Tablet | 1.11USD | tablet |
| Enalapril maleate 10 mg tablet | 1.09USD | tablet |
| Enalapril maleate 5 mg tablet | 1.03USD | tablet |
| Vasotec 5 mg Tablet | 0.92USD | tablet |
| Enalapril maleate 2.5 mg tablet | 0.82USD | tablet |
| Vasotec 2.5 mg Tablet | 0.,78USD | tablet |
| Apo-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Co Enalapril 20 mg Tablet | 0.75USD | tablet |
| Mylan-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Novo-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Pms-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Ratio-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Sandoz Enalapril 20 mg Tablet | 0.,75USD | tablet |
| Taro-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Apo-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Co Enalapril 10 mg Tablet | 0.62USD | tablet |
| Mylan-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Novo-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Pms-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Ratio-Enalapril 10 mg Tablet | 0.,62USD | tablet |
| Sandoz Enalapril 10 mg Tablet | 0.62USD | tablet |
| Taro-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Apo-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Co Enalapril 5 mg Tablet | 0.52USD | tablet |
| Mylan-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Novo-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Pms-Enalapril 5 mg Tablet | 0.,52USD | tablet |
| Ratio-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Sandoz Enalapril 5 mg Tablet | 0.52USD | tablet |
| Taro-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Apo-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Co Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Mylan-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Novo-Enalapril 2.5 mg Tablet | 0.,44USD | tablet |
| Pms-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Ratio-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Sandoz Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Taro-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.,
Patents
Properties
State Solid Experimental Properties Predicted Properties
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.213 mg/mL | ALOGPS |
| logP | 0.19 | ALOGPS |
| logP | 0.59 | ChemAxon |
| logS | -3.2 | ALOGPS |
| pKa (Strongest Acidic) | 3.,67 | ChemAxon |
| pKa (Strongest Basic) | 5.2 | ChemAxon |
| Physiological Charge | -1 | ChemAxon |
| Hydrogen Acceptor Count | 5 | ChemAxon |
| Hydrogen Donor Count | 2 | ChemAxon |
| Polar Surface Area | 95.94 Å2 | ChemAxon |
| Rotatable Bond Count | 10 | ChemAxon |
| Refractivity | 99.57 m3·mol-1 | ChemAxon |
| Polarizability | 40., | ChemAxon |
| Rule of Five | Yes | ChemAxon |
| Ghose Filter | Yes | ChemAxon |
| Veber’s Rule | No | ChemAxon |
| MDDR-like Rule | No | ChemAxon |
Predicted ADMET Features
| Property | Value | Probability |
|---|---|---|
| Human Intestinal Absorption | + | 0.,7428 |
| Blood Brain Barrier | – | 0.9659 |
| Caco-2 permeable | – | 0.8956 |
| P-glycoprotein substrate | Substrate | 0.7691 |
| P-glycoprotein inhibitor I | Non-inhibitor | 0.6681 |
| P-glycoprotein inhibitor II | Non-inhibitor | 0.5136 |
| Renal organic cation transporter | Non-inhibitor | 0.8442 |
| CYP450 2C9 substrate | Non-substrate | 0.,8632 |
| CYP450 2D6 substrate | Non-substrate | 0.9116 |
| CYP450 3A4 substrate | Non-substrate | 0.5696 |
| CYP450 1A2 substrate | Non-inhibitor | 0.9125 |
| CYP450 2C9 inhibitor | Non-inhibitor | 0.9154 |
| CYP450 2D6 inhibitor | Non-inhibitor | 0.9231 |
| CYP450 2C19 inhibitor | Non-inhibitor | 0.9025 |
| CYP450 3A4 inhibitor | Non-inhibitor | 0.,8309 |
| CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.6825 |
| Ames test | Non AMES toxic | 0.9383 |
| Carcinogenicity | Non-carcinogens | 0.9216 |
| Biodegradation | Not ready biodegradable | 0.8686 |
| Rat acute toxicity | 1.8269 LD50, mol/kg | Not applicable |
| hERG inhibition (predictor I) | Weak inhibitor | 0.,9719 |
| hERG inhibition (predictor II) | Non-inhibitor | 0.7456 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,=”720f1a1b08″>
Details
Binding Properties1., Angiotensin-converting enzyme
soort Eiwitorganisme mensen farmacologische werking
Ja
Effecten
remmer
algemene functie specifieke functie Zinkionbinding zet angiotensine I om in angiotensine II door afgifte van de terminale His-Leu, hetgeen resulteert in een verhoging van de vasoconstrictor activiteit van angiotensine. Ook in staat om bradykinin te inactiveren, een krachtige… Gennaam ACE Uniprot ID P12821 Uniprot naam angiotensine-converterend enzym molecuulgewicht 149713.,675 Da
- Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: thermodynamische bepaling van de bindingsconstanten van angiotensine-converting enzyme-remmers door middel van een verdringingsmethode. FEBS Lett. 2007 Jul 24; 581(18): 3449-54. Epub 2007 Jun 27.
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleïnezuren Res.2002 Jan 1;30(1):412-5.
- Liu YH, Liu LY, Wu JX, Chen SX, Sun YX: Comparison of captopril and Enalapril to study the role of the sulfhydryl-group in improvement of endothelial disfunctie with ACE inhibitors in high dieted methionine muizen., J Cardiovasc Pharmacol. 2006 Jan; 47 (1): 82-8.
- Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR: Structural details on the binding of antihypertensiva captopril and enalaprilaat to human testiculaire angiotensine I-converting enzyme. Biochemie. 2004 Jul 13; 43(27): 8718-24.
dragers
Details1., Serumalbumine
soort Eiwitorganisme mensen farmacologische werking
geen
acties
bindmiddel
algemene functie toxische stofbindende specifieke functie serumalbumine, het belangrijkste plasmaeiwit, heeft een goed bindingsvermogen voor water, Ca(2+), Na(+), K(+), vetzuren, hormonen, bilirubine en geneesmiddelen. De belangrijkste functie is de regulatie van het colloïd… Gen naam Alb Uniprot ID P02768 Uniprot naam Serum albumine molecuulgewicht 69365.,Da
- Trbojevic-Stankovic J, Aleksic M, Odovic J: Estimation of angiotensine-converting enzyme inhibitors protein binding degree using chromatographic hydrophobicity data. Srp Arh Celok Lek. 2015 Jan-Feb; 143 (1-2): 50-5.,
Transporters
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Gene Name ABCB1 Uniprot ID P08183 Uniprot Name Multidrug resistance protein 1 Molecular Weight 141477.,Da
- Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: interactie van digoxine met antihypertensiva via MDR1. Life Sci. 2002 Feb 15; 70 (13): 1491-500.,div>
Binding Properties
×
Property Measurement pH Temperature (°C) IC 50 (nM) 15000000 N/A N/A 9706043 IC 50 (nM) 4500000 N/A N/A 10052994
Details
Binding Properties2., 15 lid 1
soort Eiwitorganisme mensen farmacologische werking
onbekend
acties
substraat
Inhibitor
algemene functie Proton-afhankelijke oligopeptide secundaire actieve transmembraantransporteractiviteit specifieke functie Proton-gekoppelde inname van oligopeptiden van 2 tot 4 aminozuren met een voorkeur voor dipeptiden. Kan een belangrijke route voor de absorptie van eiwit spijsvertering eindproducten vormen. Gennaam SLC15A1 Uniprot ID P46059 Uniprot naam Solute carrier familie 15 lid 1 molecuulgewicht 78805.,Da
- Han H, De Vrüh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadee W, Amidon GL: 5′-Aminozuuresters van antivirale nucleosiden, acyclovir en AZT worden geabsorbeerd door de intestinale PEPT1 peptide transporter. Pharm Res. 1998 Aug; 15 (8):1154-9.
- Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hpept1 cells overexpressing The human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 mrt; 88 (3):347-50.,
- Temple CS, Boyd CA: Proton-coupled oligopeptide transport by rat renal cortical brush border membraan vesicles: a functional analysis using ACE inhibitors to determinate the isoform of the transporter. Biochim Biophys Acta. 1998 Aug 14; 1373 (1): 277-81.
- Tsuji a: Transporter-gemedieerde geneesmiddelinteracties. Drug Metab Farmacokinet. 2002;17(4):253-74.,
soort Eiwitorganisme mensen farmacologische actie
onbekend
acties
Inhibitor
algemene functie Natriumonafhankelijke organische anion transmembraantransporteur activiteitspecifieke functie betrokken bij de renale eliminatie van endogene en exogene organische anionen. Functioneert als organische anionenwisselaar wanneer de opname van één molecuul van organische anion aan een efflux van één wordt gekoppeld … Gennaam SLC22A6 Uniprot ID Q4U2R8 Uniprot naam oplosbare drager familie 22 lid 6 molecuulgewicht 61815.,78 Da
- Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: heterologe expressie en functionele karakterisering van een muis renale organische anion transporter in zoogdiercellen. J Biol Chem. 1999 Jan 15;274 (3): 1519-24.,
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad… Gene Name SLC22A8 Uniprot ID Q8TCC7 Uniprot Name Solute carrier family 22 member 8 Molecular Weight 59855.,Da
- Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 mei; 32 (5): 479-83.,
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulf… Gene Name SLC22A7 Uniprot ID Q9Y694 Uniprot Name Solute carrier family 22 member 7 Molecular Weight 60025.,025 Da
- Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gen expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul; 62 (1):7-14.
- Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima n, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 predominantly in the liver. FEBS Lett. 1998 Jun 12; 429 (2): 179-82.,
Soort Eiwit Organisme van de Mens Farmacologische actie
Onbekend
Acties
Substraat
Algemene Functie Natrium-onafhankelijke organische anion transmembraan transporter activiteit Specifieke Functie Bemiddelt de Na(+)-transport van organische anionen zoals sulfobromophthalein (BSP) en geconjugeerd (taurocholate) en unconjugated (cholate) galzuren (Door de overeenkomst). Selectief remmen…, Gennaam SLCO1A2 Uniprot ID P46721 Uniprot Name Solute carrier organic anion transporter family member 1A2 Molecular Weight 74144.105 Da
- Abu-Zahra TN, Wolkoff AW, Kim RB, Pang KS: Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonale, geïsoleerde rattenhepatocyten. Drug Metab Dispos. 2000 Jul; 28 (7): 801-6.
- Pang KS, Wang PJ, Chung AY, Wolkoff AW: het gemodificeerde dipeptide, enalapril, een angiotensin-converting enzyme inhibitor, wordt getransporteerd door het rat lever organic anion transport protein. Hepatologie. 1998 Nov; 28 (5):1341-6.,
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geneesmiddel aangemaakt op 13 juni 2005 07: 24 / bijgewerkt op 08 februari 2021 05:13