Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Tablet | Oral | |
| Tablet | Oral | 10 MG |
| Tablet | Oral | 20 MG |
| Tablet | Oral | 5 MG |
| Powder, for suspension | Oral | 0.006 g |
| Tablet | Oral | 5.,254 mg |
| Tablet, film coated | Oral | 10 mg/1 |
| Tablet, film coated | Oral | 20 mg/1 |
| Tablet | Oral | 12.5 mg |
| Tablet | Oral | 2.5 MG |
| Capsule, coated | Oral | 2.,5 mg |
| Capsule, coated | Oral | 5 mg |
| Tablet | Oral | 6 mg |
| Tablet | Oral | 30 MG |
| Tablet | Oral | 40 MG |
| Suspension | Oral | 1 mg/1mL |
| Suspension | Oral | 500 mcg/1mL |
| Syrup | 1 mg/1mL | |
| Tablet, film coated | Oral | 5 mg |
| Tablet | Oral | 5.,1 mg |
| Tablet, coated | Oral | 10 MG |
| Tablet | Oral | 10 mg/1 |
| Tablet | Oral | 2.5 mg/1 |
| Tablet | Oral | 20 mg/1 |
| Tablet | Oral | 5 mg/1 |
| Tablet, soluble | Oral | 10 mg/1 |
| Tablet, soluble | Oral | 2.,5 mg/1 |
| Tablet, soluble | Oral | 20 mg/1 |
| Tablet, soluble | Oral | 5 mg/1 |
| Tablet | Oral | |
| Tablet | Oral | 20., mg |
| Tablet | Oral | 2 mg |
| Tablet | Oral | 4 mg |
| Tablet | Oral | 8 mg |
| Tablet, film coated | Oral | 10 mg |
| Tablet, film coated | Oral | 20 mg |
Prices
| Unit description | Cost | Unit |
|---|---|---|
| Enalapril maleate powder | 9.,18USD | g |
| Enalaprilat 1.25 mg/ml vial | 3.6USD | ml |
| Vasotec 20 mg tablet | 3.36USD | tablet |
| Vaseretic 10-25 mg tablet | 3.15USD | tablet |
| Vasotec 10 mg tablet | 2.63USD | tablet |
| Vasotec 5 mg tablet | 2.08USD | tablet |
| Vasotec 2.5 mg tablet | 1.65USD | tablet |
| Enalapril maleate 20 mg tablet | 1.56USD | tablet |
| Vaseretic 5-12.,5 mg tablet | 1.49USD | tablet |
| Vasotec 20 mg Tablet | 1.34USD | tablet |
| Vasotec 10 mg Tablet | 1.11USD | tablet |
| Enalapril maleate 10 mg tablet | 1.09USD | tablet |
| Enalapril maleate 5 mg tablet | 1.03USD | tablet |
| Vasotec 5 mg Tablet | 0.92USD | tablet |
| Enalapril maleate 2.5 mg tablet | 0.82USD | tablet |
| Vasotec 2.5 mg Tablet | 0.,78USD | tablet |
| Apo-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Co Enalapril 20 mg Tablet | 0.75USD | tablet |
| Mylan-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Novo-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Pms-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Ratio-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Sandoz Enalapril 20 mg Tablet | 0.,75USD | tablet |
| Taro-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Apo-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Co Enalapril 10 mg Tablet | 0.62USD | tablet |
| Mylan-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Novo-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Pms-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Ratio-Enalapril 10 mg Tablet | 0.,62USD | tablet |
| Sandoz Enalapril 10 mg Tablet | 0.62USD | tablet |
| Taro-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Apo-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Co Enalapril 5 mg Tablet | 0.52USD | tablet |
| Mylan-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Novo-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Pms-Enalapril 5 mg Tablet | 0.,52USD | tablet |
| Ratio-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Sandoz Enalapril 5 mg Tablet | 0.52USD | tablet |
| Taro-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Apo-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Co Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Mylan-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Novo-Enalapril 2.5 mg Tablet | 0.,44USD | tablet |
| Pms-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Ratio-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Sandoz Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Taro-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.,
Patents
Properties
State Solid Experimental Properties Predicted Properties
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.213 mg/mL | ALOGPS |
| logP | 0.19 | ALOGPS |
| logP | 0.59 | ChemAxon |
| logS | -3.2 | ALOGPS |
| pKa (Strongest Acidic) | 3.,67 | ChemAxon |
| pKa (Strongest Basic) | 5.2 | ChemAxon |
| Physiological Charge | -1 | ChemAxon |
| Hydrogen Acceptor Count | 5 | ChemAxon |
| Hydrogen Donor Count | 2 | ChemAxon |
| Polar Surface Area | 95.94 Å2 | ChemAxon |
| Rotatable Bond Count | 10 | ChemAxon |
| Refractivity | 99.57 m3·mol-1 | ChemAxon |
| Polarizability | 40., | ChemAxon |
| Rule of Five | Yes | ChemAxon |
| Ghose Filter | Yes | ChemAxon |
| Veber’s Rule | No | ChemAxon |
| MDDR-like Rule | No | ChemAxon |
Predicted ADMET Features
| Property | Value | Probability |
|---|---|---|
| Human Intestinal Absorption | + | 0.,7428 |
| Blood Brain Barrier | – | 0.9659 |
| Caco-2 permeable | – | 0.8956 |
| P-glycoprotein substrate | Substrate | 0.7691 |
| P-glycoprotein inhibitor I | Non-inhibitor | 0.6681 |
| P-glycoprotein inhibitor II | Non-inhibitor | 0.5136 |
| Renal organic cation transporter | Non-inhibitor | 0.8442 |
| CYP450 2C9 substrate | Non-substrate | 0.,8632 |
| CYP450 2D6 substrate | Non-substrate | 0.9116 |
| CYP450 3A4 substrate | Non-substrate | 0.5696 |
| CYP450 1A2 substrate | Non-inhibitor | 0.9125 |
| CYP450 2C9 inhibitor | Non-inhibitor | 0.9154 |
| CYP450 2D6 inhibitor | Non-inhibitor | 0.9231 |
| CYP450 2C19 inhibitor | Non-inhibitor | 0.9025 |
| CYP450 3A4 inhibitor | Non-inhibitor | 0.,8309 |
| CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.6825 |
| Ames test | Non AMES toxic | 0.9383 |
| Carcinogenicity | Non-carcinogens | 0.9216 |
| Biodegradation | Not ready biodegradable | 0.8686 |
| Rat acute toxicity | 1.8269 LD50, mol/kg | Not applicable |
| hERG inhibition (predictor I) | Weak inhibitor | 0.,9719 |
| hERG inhibition (predictor II) | Non-inhibitor | 0.7456 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,=»720f1a1b08″>
Details
Binding Properties1., Enzima convertidora de angiotensina
tipo de Organismo proteico humano acción farmacológica
Sí
acciones
inhibidor
función General Unión de iones de Zinc función específica convierte la angiotensina I a la angiotensina II mediante la liberación del terminal His-Leu, esto resulta en un aumento de la actividad vasoconstrictora de la angiotensina. También capaz de inactivar la bradiquinina, un potente… Nombre del gen Ace UniProt ID P12821 nombre de UniProt enzima convertidora de angiotensina peso Molecular 149713.,675 Da
- Andujar-Sanchez M, Jara-Perez V, Camara-Artigas a: determinación Termodinámica de las constantes de unión de los inhibidores de la enzima convertidora de angiotensina mediante un método de desplazamiento. Febs Lett. 2007 Jul 24; 581(18): 3449-54. Epub 2007 Jun 27.
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30 (1): 412-5.
- Liu YH, Liu LY, Wu JX, Chen SX, Sun YX: comparación de captopril y Enalapril para estudiar el papel del grupo sulfhidrilo en la mejora de la disfunción endotelial con inhibidores de la ECA en ratones metionina con dieta alta., J Cardiovasc Pharmacol. 2006 Jan;47(1): 82-8.
- Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR: Structural details on The binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensina I-converting enzyme. Bioquímica. 2004 Jul 13; 43(27): 8718-24.
Transportistas
Details1., Serum albumin
Kind Protein Organism Humans Pharmacological action
no
Actions
Binder
función General de unión de sustancias tóxicas función específica la albúmina sérica, la proteína principal del plasma, tiene una buena capacidad de unión para agua, Ca (2+), Na (+), K (+), ácidos grasos, hormonas, bilirrubina y medicamentos. Su función principal es la regulación del coloide… Gen nombre ALB UniProt ID P02768 nombre UniProt albúmina sérica peso Molecular 69365.,94 Da
- Trbojevic-Stankovic J, Aleksic M, Odovic J: Estimation of angiotensina-converting enzyme inhibitors protein binding degree using chromatographic hydrophobicity data. Srp Arh Celok Lek. 2015 Jan-Feb; 143(1-2): 50-5.,
Transporters
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Gene Name ABCB1 Uniprot ID P08183 Uniprot Name Multidrug resistance protein 1 Molecular Weight 141477.,255 Da
- Takara K, Kakumoto M, Tanigawara y, Funakoshi J, Sakaeda T, Okumura K: interacción de la digoxina con medicamentos antihipertensivos a través de MDR1. Life Sci. 2002 Feb 15;70 (13): 1491-500.,div>
Binding Properties
×
Property Measurement pH Temperature (°C) IC 50 (nM) 15000000 N/A N/A 9706043 IC 50 (nM) 4500000 N/A N/A 10052994
Details
Binding Properties2., Familia de portadores de soluto 15 miembro 1
tipo de proteína organismo humano acción farmacológica
Desconocido
acciones
sustrato
inhibidor
función general oligopéptido dependiente de protones actividad secundaria activa del transportador transmembrana función específica ingesta de oligopéptidos acoplados a protones de 2 a 4 aminoácidos con preferencia por dipéptidos. Puede constituir una vía importante para la absorción de los productos finales de digestión de proteínas. Nombre del gen SLC15A1 identificación de Uniprot P46059 nombre de UniProt familia de portadores de soluto 15 miembros 1 peso Molecular 78805.,265 Da
- Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadee W, Amidon GL: 5′-ésteres de aminoácidos de nucleósidos antivirales, aciclovir y AZT son absorbidos por el transportador de péptidos pept1 intestinal. Pharm Res. 1998 Aug;15(8): 1154-9.
- han HK, Rhie JK, Oh DM, Saito G, HSU CP, Stewart BH, Amidon GL: cho/hpept1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar; 88 (3): 347-50.,
- Temple CS, Boyd CA: Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter. Biochim Biophys Acta. 1998 Aug 14;1373 (1): 277-81.
- Tsuji a: Interacciones medicamentosas mediadas por transportadores. Drogas Metab Pharmacokinet. 2002;17(4):253-74.,
tipo de proteína organismo humano acción farmacológica
Desconocido
acciones
inhibidor
función General actividad transportadora transmembrana de aniones orgánicos independiente del sodio función específica involucrada en la eliminación renal de aniones orgánicos endógenos y exógenos. Funciona como intercambiador de aniones orgánicos cuando la absorción de una molécula de anión orgánico se acopla con un flujo de uno … Nombre del gen SLC22A6 identificación de UniProt Q4U2R8 nombre de UniProt familia de portadores de soluto 22 miembros 6 peso Molecular 61815.,78 Da
- Kuze K, Graves P, Leahy a, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15; 274 (3): 1519-24.,
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad… Gene Name SLC22A8 Uniprot ID Q8TCC7 Uniprot Name Solute carrier family 22 member 8 Molecular Weight 59855.,585 Da
- Kobayashi y, Ohshiro N, Tsuchiya a, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Dispos De Metab De Drogas. 2004 May; 32 (5): 479-83.,
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulf… Gene Name SLC22A7 Uniprot ID Q9Y694 Uniprot Name Solute carrier family 22 member 7 Molecular Weight 60025.,025 Da
- Kobayashi y, Ohshiro N, Shibusawa a, Sasaki T, Tokuyama s, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul; 62 (1): 7-14.
- Sekine t, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai y, Endou H: Identificación del transportador multiespecífico de aniones orgánicos 2 expresado predominantemente en el hígado. Febs Lett. 1998 Jun 12; 429 (2): 179-82.,
tipo de proteína organismo humano acción farmacológica
Desconocido
acciones
sustrato
función General actividad transportadora transmembrana de aniones orgánicos independientes de sodio función específica Media el transporte independiente de aniones orgánicos como sulfobromoftaleína (BSP) y conjugado (taurocolato) y ácidos biliares no conjugados (colados) (por similitud). Inhibir selectivamente…, Gene Name SLCO1A2 UniProt ID P46721 UniProt Name solute carrier organic anion transporter family member 1A2 Molecular Weight 74144.105 Da
- Abu-Zahra TN, Wolkoff AW, Kim RB, Pang KS: Uptake of Enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Dispos De Metab De Drogas. 2000 Jul;28(7): 801-6.
- Pang KS, Wang PJ, Chung AY, Wolkoff AW: el dipéptido modificado, enalapril, un inhibidor de la enzima convertidora de angiotensina, es transportado por la proteína de transporte de aniones orgánicos del hígado de rata. Hepatología. 1998 Nov; 28 (5): 1341-6.,
×
Mejorar los resultados del paciente
Construir herramientas de soporte de decisiones con el más completo de la industria de interacción fármaco-fármaco de corrector.
más información
de Drogas creado el 13 de junio de 2005 07:24 / Actualizado 08 de febrero de 2021 05:13