Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Tablet | Oral | |
| Tablet | Oral | 10 MG |
| Tablet | Oral | 20 MG |
| Tablet | Oral | 5 MG |
| Powder, for suspension | Oral | 0.006 g |
| Tablet | Oral | 5.,254 mg |
| Tablet, film coated | Oral | 10 mg/1 |
| Tablet, film coated | Oral | 20 mg/1 |
| Tablet | Oral | 12.5 mg |
| Tablet | Oral | 2.5 MG |
| Capsule, coated | Oral | 2.,5 mg |
| Capsule, coated | Oral | 5 mg |
| Tablet | Oral | 6 mg |
| Tablet | Oral | 30 MG |
| Tablet | Oral | 40 MG |
| Suspension | Oral | 1 mg/1mL |
| Suspension | Oral | 500 mcg/1mL |
| Syrup | 1 mg/1mL | |
| Tablet, film coated | Oral | 5 mg |
| Tablet | Oral | 5.,1 mg |
| Tablet, coated | Oral | 10 MG |
| Tablet | Oral | 10 mg/1 |
| Tablet | Oral | 2.5 mg/1 |
| Tablet | Oral | 20 mg/1 |
| Tablet | Oral | 5 mg/1 |
| Tablet, soluble | Oral | 10 mg/1 |
| Tablet, soluble | Oral | 2.,5 mg/1 |
| Tablet, soluble | Oral | 20 mg/1 |
| Tablet, soluble | Oral | 5 mg/1 |
| Tablet | Oral | |
| Tablet | Oral | 20., mg |
| Tablet | Oral | 2 mg |
| Tablet | Oral | 4 mg |
| Tablet | Oral | 8 mg |
| Tablet, film coated | Oral | 10 mg |
| Tablet, film coated | Oral | 20 mg |
Prices
| Unit description | Cost | Unit |
|---|---|---|
| Enalapril maleate powder | 9.,18USD | g |
| Enalaprilat 1.25 mg/ml vial | 3.6USD | ml |
| Vasotec 20 mg tablet | 3.36USD | tablet |
| Vaseretic 10-25 mg tablet | 3.15USD | tablet |
| Vasotec 10 mg tablet | 2.63USD | tablet |
| Vasotec 5 mg tablet | 2.08USD | tablet |
| Vasotec 2.5 mg tablet | 1.65USD | tablet |
| Enalapril maleate 20 mg tablet | 1.56USD | tablet |
| Vaseretic 5-12.,5 mg tablet | 1.49USD | tablet |
| Vasotec 20 mg Tablet | 1.34USD | tablet |
| Vasotec 10 mg Tablet | 1.11USD | tablet |
| Enalapril maleate 10 mg tablet | 1.09USD | tablet |
| Enalapril maleate 5 mg tablet | 1.03USD | tablet |
| Vasotec 5 mg Tablet | 0.92USD | tablet |
| Enalapril maleate 2.5 mg tablet | 0.82USD | tablet |
| Vasotec 2.5 mg Tablet | 0.,78USD | tablet |
| Apo-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Co Enalapril 20 mg Tablet | 0.75USD | tablet |
| Mylan-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Novo-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Pms-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Ratio-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Sandoz Enalapril 20 mg Tablet | 0.,75USD | tablet |
| Taro-Enalapril 20 mg Tablet | 0.75USD | tablet |
| Apo-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Co Enalapril 10 mg Tablet | 0.62USD | tablet |
| Mylan-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Novo-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Pms-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Ratio-Enalapril 10 mg Tablet | 0.,62USD | tablet |
| Sandoz Enalapril 10 mg Tablet | 0.62USD | tablet |
| Taro-Enalapril 10 mg Tablet | 0.62USD | tablet |
| Apo-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Co Enalapril 5 mg Tablet | 0.52USD | tablet |
| Mylan-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Novo-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Pms-Enalapril 5 mg Tablet | 0.,52USD | tablet |
| Ratio-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Sandoz Enalapril 5 mg Tablet | 0.52USD | tablet |
| Taro-Enalapril 5 mg Tablet | 0.52USD | tablet |
| Apo-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Co Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Mylan-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Novo-Enalapril 2.5 mg Tablet | 0.,44USD | tablet |
| Pms-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Ratio-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Sandoz Enalapril 2.5 mg Tablet | 0.44USD | tablet |
| Taro-Enalapril 2.5 mg Tablet | 0.44USD | tablet |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.,
Patents
Properties
State Solid Experimental Properties Predicted Properties
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.213 mg/mL | ALOGPS |
| logP | 0.19 | ALOGPS |
| logP | 0.59 | ChemAxon |
| logS | -3.2 | ALOGPS |
| pKa (Strongest Acidic) | 3.,67 | ChemAxon |
| pKa (Strongest Basic) | 5.2 | ChemAxon |
| Physiological Charge | -1 | ChemAxon |
| Hydrogen Acceptor Count | 5 | ChemAxon |
| Hydrogen Donor Count | 2 | ChemAxon |
| Polar Surface Area | 95.94 Å2 | ChemAxon |
| Rotatable Bond Count | 10 | ChemAxon |
| Refractivity | 99.57 m3·mol-1 | ChemAxon |
| Polarizability | 40., | ChemAxon |
| Rule of Five | Yes | ChemAxon |
| Ghose Filter | Yes | ChemAxon |
| Veber’s Rule | No | ChemAxon |
| MDDR-like Rule | No | ChemAxon |
Predicted ADMET Features
| Property | Value | Probability |
|---|---|---|
| Human Intestinal Absorption | + | 0.,7428 |
| Blood Brain Barrier | – | 0.9659 |
| Caco-2 permeable | – | 0.8956 |
| P-glycoprotein substrate | Substrate | 0.7691 |
| P-glycoprotein inhibitor I | Non-inhibitor | 0.6681 |
| P-glycoprotein inhibitor II | Non-inhibitor | 0.5136 |
| Renal organic cation transporter | Non-inhibitor | 0.8442 |
| CYP450 2C9 substrate | Non-substrate | 0.,8632 |
| CYP450 2D6 substrate | Non-substrate | 0.9116 |
| CYP450 3A4 substrate | Non-substrate | 0.5696 |
| CYP450 1A2 substrate | Non-inhibitor | 0.9125 |
| CYP450 2C9 inhibitor | Non-inhibitor | 0.9154 |
| CYP450 2D6 inhibitor | Non-inhibitor | 0.9231 |
| CYP450 2C19 inhibitor | Non-inhibitor | 0.9025 |
| CYP450 3A4 inhibitor | Non-inhibitor | 0.,8309 |
| CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.6825 |
| Ames test | Non AMES toxic | 0.9383 |
| Carcinogenicity | Non-carcinogens | 0.9216 |
| Biodegradation | Not ready biodegradable | 0.8686 |
| Rat acute toxicity | 1.8269 LD50, mol/kg | Not applicable |
| hERG inhibition (predictor I) | Weak inhibitor | 0.,9719 |
| hERG inhibition (predictor II) | Non-inhibitor | 0.7456 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,=”720f1a1b08″>
Details
Binding Properties1., Angiotensin-konverterende enzym
Slags Protein Organisme Mennesker Farmakologiske indsats
Ja
Handlinger
– Hæmmer
Generelle Funktion Zink-ion-bindende Specifikke Funktion, der Omdanner angiotensin i til angiotensin II ved udgivelsen af terminalen Hans-Leu, dette resulterer i en stigning af vasokonstriktor aktivitet af angiotensin. Også i stand til at inaktivere bradykinin, en potent… Gen ved Navn ACE Uniprot-ID P12821 Uniprot Navn Angiotensin-converting enzym Molekylær Vægt 149713.,675 Da
- Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Termodynamiske fastsættelse af bindende konstanter af angiotensin-konvertering-enzym-hæmmere ved en forskydning metode. Februar Lett. 2007 juli 24; 581(18):3449-54. Epub 2007 27. Juni.
- Chen,, Ji ,l, Chen y.: TTD: terapeutisk måldatabase. 2002 Jan 1;30(1):412-5.
- Liu YH, Liu LY, Wu JX, Chen SX, Solen YX: Sammenligning af captopril og enalapril at studere den rolle, sulfhydryl-gruppen i forbedring af endothelial dysfunktion med ACE-hæmmere i høj dieted methionin mus., J Cardiovasc Pharmacol. 2006 Jan;47 (1): 82-8.
- Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR: Strukturelle detaljer om binding af antihypertensiv medicin captopril og enalaprilat til menneskelige testikelkræft angiotensin I-konverterende enzym. Biokemisk. 2004 juli 13; 43(27):8718-24.
Luftfartsselskaber
Details1., Serum-albumin
Slags Protein Organisme Mennesker Farmakologiske indsats
Nej
Handlinger
Bindemiddel
Generelle Funktion Giftigt stof, der er bindende Bestemt Funktion Serum albumin, det vigtigste protein i plasma, har en god bindende kapacitet for vand, Ca(2+), Na(+), K, (+), fedtsyrer, hormoner, bilirubin og narkotika. Hovedfunktionen er reguleringen af kolloidet… Gen Navn ALB Uniprot-ID P02768 Uniprot Navn Serum albumin Molekylær Vægt 69365.,94 Da
- Trbojevic-Stankovic J, Aleksic M, Odovic J: Estimering af angiotensin-konvertering-enzym-hæmmere protein bindende grad ved hjælp af kromatografiske hydrophobicity data. Srp Arh Celok Lek. 2015 Jan-Februar; 143 (1-2):50-5.,
Transporters
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Gene Name ABCB1 Uniprot ID P08183 Uniprot Name Multidrug resistance protein 1 Molecular Weight 141477.,255 Da
- Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Samspillet af digoxin med antihypertensiva via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500.,div>
Binding Properties
×
Property Measurement pH Temperature (°C) IC 50 (nM) 15000000 N/A N/A 9706043 IC 50 (nM) 4500000 N/A N/A 10052994
Details
Binding Properties2., Opløst stof carrier familien 15-1
Slags Protein Organisme Mennesker Farmakologiske indsats
Ukendt
Handlinger
Substrat
Inhibitor
Generelle Funktion Proton-afhængige oligopeptide sekundær aktiv transmembrane transporter aktivitet Bestemt Funktion Proton-kombineret indtagelse af oligopeptides af 2 til 4 aminosyrer med en præference for dipeptides. Kan udgøre en vigtig vej til absorption af slutprodukter til proteinfordøjelse. Gene navn SLC15A1 Uniprot ID P46059 Uniprot navn opløst carrier familie 15 medlem 1 molekylvægt 78805.,265 Da
- Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadee W, Amidon GL: 5′-Amino syrer estere af antivirale nucleosides, acyclovir, og AZT absorberes af tarmen PEPT1 peptid-transporter. 1998 Aug;15(8):1154-9.
- Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 celler overexpressing den menneskelige peptid-transporter (hPEPT1) som et alternativ til in vitro-model for peptidomimetic lægemidler. J. Pharm Sci. 1999 Mar;88(3):347-50.,
- Temple CS, Boyd CA: Protonkoblet oligopeptidtransport med rotte-renale kortikale børstegrænsemembranvesikler: en funktionel analyse ved hjælp af ACE-hæmmere til bestemmelse af transportørens isoform. Biochim Biophys Acta. 1998 14. August; 1373 (1): 277-81.
- Tsuji a: Transporter-medierede lægemiddelinteraktioner. Stof Metabetet. 2002;17(4):253-74.,
Slags Protein Organisme Mennesker Farmakologiske indsats
Ukendt
Handlinger
– Hæmmer
Generelle Funktion Natrium-uafhængig organisk anion transmembrane transporter aktivitet Særlige Funktion, der er Involveret i den renale elimination af endogene og eksogene organiske anioner. Fungerer som organisk anionveksler, når optagelsen af et molekyle organisk anion kobles med en udstrømning af en … Gene navn SLC22A6 Uniprot ID44U2R8 Uniprot navn opløst carrier familie 22 medlem 6 molekylvægt 61815.,78 Da
- Kuze K, Grave, P, Leahy En, Wilson S, Stuhlmann H, G: Heterolog ekspression og funktionel karakterisering af en mus renal organisk anion transporter i pattedyrceller. J Biol Chem. 1999 15.januar;274(3):1519-24.,
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad… Gene Name SLC22A8 Uniprot ID Q8TCC7 Uniprot Name Solute carrier family 22 member 8 Molecular Weight 59855.,585 Da
- Kobayashi Y, Ohshiro N, Tsuchiya En, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport af organiske forbindelser, medieret af musen organisk anion transporter 3 (mOat3): yderligere substrat specificitet af mOat3. Stof Metab Dispos. 2004 Maj; 32 (5):479-83.,
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inhibitor
General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulf… Gene Name SLC22A7 Uniprot ID Q9Y694 Uniprot Name Solute carrier family 22 member 7 Molecular Weight 60025.,025 Da
- Kobayashi Y, Ohshiro N, Shibusawa En, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolering, karakterisering og differentiel gen-ekspression af multispecific organisk anion transporter 2 i mus. Mol Pharmacol. 2002 Jul; 62 (1):7-14.
- Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identifikation af multispecific organisk anion transporter 2 overvejende i leveren. Februar Lett. 1998 12. juni; 429 (2): 179-82.,
Slags Protein Organisme Mennesker Farmakologiske indsats
Ukendt
Handlinger
Substrat
Generelle Funktion Natrium-uafhængig organisk anion transmembrane transporter aktivitet Specifikke Funktion, der Formidler Na(+)-uafhængig transport af organiske anioner som f.eks sulfobromophthalein (BSP) og konjugeret (taurocholate) og unconjugated (cholate) galdesyrer (Ved lighed). Selektivt hæmme…, Gen Navn SLCO1A2 Uniprot-ID P46721 Uniprot Navn Opløst bærer organisk anion transporter familiemedlem 1A2 Molekylær Vægt 74144.105 Da
- Abu-Zahra TN, Wolkoff AW, Kim RB, Pang AA: Optagelse af enalapril og udtryk af organisk anion, der transporterer polypeptid 1 i zoner, isolerede rotte leverceller. Stof Metab Dispos. 2000 Juli; 28 (7):801-6.
- Pang KS, ,ang PJ, Chung AY, Wololkoff A.: det modificerede dipeptid, enalapril, en angiotensin-konverterende en .yminhibitor, transporteres af rotteleverens organiske aniontransportprotein. Hepatologi. 1998 Nov;28(5):1341-6.,
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lægemiddel oprettet den 13. juni 2005 07: 24 / opdateret den 08. februar 2021 05: 13